SCIENTIFIC AGENDA
ASR reserves the right to substitute talks &/or speakers
SUNDAY JULY 13 |
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| 10:00 AM - 2:00 PM | Optional Whitewater Rafting Trip (see Area Attractions for details) | |
| 1:00 - 5:00 PM | REGISTRATION DESK OPEN | Salon Foyer |
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1:00 - 5:00 PM |
Poster Set Up |
Windsor Ballroom |
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3:30 – 3:35 |
Welcome & Introductions - Dan Voth, ASR President |
Grand Ballroom |
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3:35 – 4:50 |
Session 1: Epidemiology, Diagnostics, and Vaccine Development Chair: Melissa Nolan, University of South Carolina |
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| 3:35 | 1A. Keynote: Melissa Nolan, University of South Carolina - TBD | |
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4:05 |
1B. Dominica Genda, University of Missouri - The modified live attenuated vaccine (MLAV) protects against the genetically distinct human isolates of E. chaffeensis; Wakulla and Heartland, assessed in the canine infection model |
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4:20 |
1C. Andres Londono, Uniformed Services University - Whole genome analysis of a Rickettsia rickettsii isolate from a case of fatal Rocky Mountain spotted fever in Colombia |
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4:35 |
1D. Jonathan Ferm, University of Missouri - Generation of a targeted disruption mutant in Anaplasma phagocytophilum and its application as a vaccine candidate |
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4:50 - 5:15 |
COFFEE BREAK |
Grand Ballroom Foyer |
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5:15 – 6:15 |
ASR LECTURE: Rickettsial Transmission: Old is New Again Kevin Macaluso, University of South Alabama |
Grand Ballroom A |
| 6:15 - 7:00 |
PLENARY LECTURE: Tools of the Trade: Exploring Mechanisms of Host Manipulation by Wolbachia and Orientia Mark Hochstrasser, Yale University |
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7:00 – 8:30 |
WELCOME RECEPTION & DINNER |
Top of the Plaza |
MONDAY JULY 14 |
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| 7:30 - 8:30 AM |
BREAKFAST BUFFET |
Grand Ballroom Foyer |
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7:30 - 12:00 PM |
REGISTRATION DESK OPEN |
Grand Ballroom Foyer |
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8:30 – 10:15 |
Session 2: Tick-Borne Rickettsia Chair: Becky Lamason, MIT |
Grand Ballroom A |
| 8:30 |
2A. Plenary: Becky Lamason, MIT - Dissecting the cellular landscape of rickettsia-host interactions |
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| 9:00 | 2B. Keynote: Isaura Simoes, Old Dominion University - Rickettsial Strategies to Undermine Host Innate Immunity | |
| 9:30 | 2C. Brandon Sit, MIT - Genome-scale functional screening reveals host-mediated maturation of a rickettsial surface virulence factor | |
| 9:45 | 2D. Jeremy Turck, University of Tennessee - Rickettsia parkeri modulates phosphorylation of Receptor Tyrosine kinases for its survival and infection in endothelial cells | |
| 10:10 | 2E. J. Stephen Dumler, Uniformed Services University - Proposal to convene an International Committee on Systematics of Prokaryotes Rickettsia taxonomy to harmonize with current standards for prokaryotic nomenclature. | |
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10:15 – 10:30 |
COFFEE BREAK |
Grand Ballroom Foyer |
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10:30 – 12:15 |
Session 3: Anaplasma and Ehrlichia Chair: Kathryn Reif, Auburn University |
Grand Ballroom A |
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10:30 |
3A. Plenary: Jason Carlyon, Virginia Commonwealth University - Exit Strategy: Anaplasma phagocytophilum exploits exosome biogenesis and release |
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11:00 |
3B. Keynote: Ian Cadby, University of Bristol - Multi-factorial influence of the Anaplasma phagocytophilum effector, AnkA, on the actin cytoskeleton |
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11:30 |
3C. Duc-Cuong Bui, UTMB - Ehrlichia ubiquitinates and degrades nuclear alternate splicing factor hnRNPA2B1 to subvert immune response and promote infection |
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11:45 |
3D. Yasuko Rikihisa, Ohio State University - Development of an mRNA-lipid nanoparticle vaccine against emerging rickettsial pathogen Ehrlichia chaffeensis |
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12:00 |
3E. Travis Chiarelli, VCU - An Anaplasma phagocytophilum effector orchestrates regulated exocytosis for dissemination |
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| 12:15 - 1:30 | LUNCH (included) | Grand Ballroom B |
| 1:30 - 7:30 |
Free Afternoon / Optional excursion / Lunch on your own |
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| 2:00 - 5:00 |
Group Activity: River Tubing Float Trip Immerse yourself in the ultimate relaxation as you float down the French Broad River, surrounded by the breathtaking beauty of Asheville! Advance RSVP required; $30pp. Transportation included. Email us by July 2 to add |
Meet in the lobby |
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7:30 - 9:00 |
Poster Reception / Session 1 (Odd numbers) |
Windsor Ballroom |
TUESDAY JULY 15 |
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| 7:30 - 8:30 AM |
BREAKFAST BUFFET |
Grand Ballroom Foyer |
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7:30 - 3:30 PM |
REGISTRATION DESK OPEN |
Grand Ballroom Foyer |
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8:30 – 10:15 |
Session 4: Cell Biology of Infection Chair: Matteo Bonazzi, French National Center for Scientific Research |
Grand Ballroom A |
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8:30 |
4A. Plenary: Joanne Engel, University of California, San Francisco -Bacterial Mimicry of Viruses: How Chlamydia Incs employ SLiMs to Reprogram the Host |
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9:00 |
4B. Keynote: Matteo Bonazzi, French National Center for Scientific Research - New Insights into Coxiella-Containing Vacuole Biogenesis by Lipid Profiling |
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9:30 |
4C. Brigham Killips, University of Nebraska - Coxiella burnetii manipulates the host protein TFEB to promote infection |
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9:45 |
4D. Andrew Krusenstjerna, Johns Hopkins University - Employing transposon mutagenesis to interrogate the biology of Rickettsia parkeri |
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10:00 |
4E. Loka Reddy Velatooru, UTMB - Rickettsia disrupts and reduces endothelial tight junction protein zonula occludens-1 in association with inflammasome activation |
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10:15 – 10:30 |
COFFEE BREAK |
Grand Foyer & Patio |
| 10:30 - 12:00 | Poster Session 2 (Even numbers) | Windsor Ballroom |
| 12:00 - 1:15 |
LUNCH (included) |
Grand Ballroom B |
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1:15 - 3:00 |
Session 5: Host Immune Responses Against Rickettsial Agents Chair: Thomas Burke, UC Irvine |
Grand Ballroom A |
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1:15 |
5A: Plenary: Andrew Olive, Michigan State University - Dissecting the role of macrophage ontogeny during pulmonary inflammation and infection |
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1:45 |
5B: Keynote: Carrie Long, Rocky Mountain Laboratory - Intense Complexities: Modeling Coxiella burnetii-Host Interactions for Improved Q Fever Countermeasures |
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2:15 |
5C. Thomas Burke, UC Irvine - Mouse vs human nitric oxide dictates susceptibility to Rickettsia parkeri |
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2:30 |
5D. Rong Fang, UTMB - Immune correlates of neutralizing antibodies induced by vaccination with host protection against rickettsiae |
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2:45 |
5E. Johannes Doehl, NIAID - Immune-Induced Itch Drives Rapid Tick Removal in Vertebrates |
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3:00 – 3:15 |
COFFEE BREAK |
Grand Foyer & Patio |
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3:15 – 5:00 |
Session 6: Orientia Biology and Pathogenesis Chair: Mary Weber, University of Iowa |
Grand Ballroom A |
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3:15 |
6A: Plenary: Mary Weber, University of Iowa - From Chlamydia to Orientia: Dissecting Effector Function Across Intracellular Bacterial Pathogens |
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3:45 |
6B. Keynote: Lynn Soong, University of Texas Medical Branch - Immune signatures distinct to severe vs. self-limiting scrub typhus: New evidence from murine models |
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4:15 |
6C. Dario Villacreses, UTMB - Distinct Macrophage Responses Induced by Orientia tsutsugamushi Strain-Specific infection with Varying Virulence |
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4:30 |
6D. Paige Allen, VCU - Obligate intracellular Orientia tsutsugamushi impedes TP53 expression to inhibit DNA damage-induced apoptosis |
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4:45 |
6E. Christian Keller, Institute of Medical Microbiology and Hygiene - RNA sensing and autoimmunity in scrub typhus: Two sides of the same coin? |
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| 5:00 - 5:10 | BREAK | |
| 5:10 - 6:00 | ASR Business Meeting | Grand Ballroom A |
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7:00 - 9:30 |
ASR GROUP DINNER (included for registered attendee & social guests) |
Pack's Tavern |
WEDNESDAY JULY 16 |
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| 7:30 - 8:30 AM |
BREAKFAST BUFFET |
Grand Foyer & Patio |
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8:00 - 10:30 AM |
REGISTRATION DESK OPEN |
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| 7:30 - 8:30 AM | Poster Removal | Windsor |
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8:15 – 10:00 |
Session 7: Coxiella Biology and Pathogenesis Chair: Elizabeth Di Russo Case, University of Wyoming |
Grand Ballroom A |
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8:30 |
7A: Plenary: James Samuel, Texas A&M University - TBD |
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9:00 |
7B. Keynote: Elizabeth Di Russo Case, University of Wyoming - TBD |
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9:30 |
7C. Kathleen Pierce, NIH - Coxiella burnetii Nine Mile II Δcbu0533 as a suitable laboratory replacement strain |
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9:45 |
7D. Arif Sadi, University of Nebraska - Coxiella burnetii Targets the IL-17 Signaling Axis to Undermine Host Defense |
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10:00 |
7E. Shawna Reed, Quinnipiac University - Identification of growth-phase and RpoS-dependent gene promoters in Coxiella burnetii |
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10:00 - 10:15 |
COFFEE BREAK |
Grand Foyer & Patio |
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10:15 – 12:00 |
Session 8: Vector Contribution to Rickettsial Pathogenesis Chair: Adela Chavez, University of Wisconsin |
Grand Ballroom A |
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10:30 |
8A. Plenary: Lucas Tirloni, Rocky Mountain Laboratory - Blood Feeding Triggers the Terminal Differentiation of Precursor Cells in Tick Salivary Glands |
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11:00 |
8B. Keynote: Adela Oliva Chavez, University of Wisconsin - Potential regulation of wound healing responses at the skin level by EV derived miRNAs |
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11:30 |
8C. Cameron Coyle, Washington State University - Activated hemocytes mediate innate immune memory in Ixodes scapularis |
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11:45 |
8D. Kaylee Vosbigian, Washington State University - Arthropod-specific induction of stomatin by ATF6 alters cholesterol dynamics promoting pathogen infection |
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12:00 |
8E. Girish Neelakanta, University of Tennessee - Impairing transmission of Anaplasma phagocytophilum from tick |
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| 12:00 - 12:05 | Closing Remarks | |
| 12:15 - 1:45 |
Optional Lunch Workshops:
Workshop attendees pick up box lunches in foyer |
(upstairs) Victoria Room Alexander Room |
| Afternoon | DEPARTURES |
ASR Lecture
The ASR Lecture is given by a distinguished investigator that has made significant contributions to the field of rickettsial diseases. The lecturer frames past public health observations and/or scientific discoveries in the context of current research. The ASR lecture also provides the community with challenges and opportunities in the realm of basic, clinical, and translational research.