ASR 2022 AGENDA WITH ABSTRACTS
The full agenda with abstracts will only be available electronically. Please download and/or print before coming to the meeting.
AGENDA
| Saturday June 25 | |
| 3:00 PM | Welcome & Introductions - Kevin Macaluso, ASR President |
| Session 1: Advances in clinical diagnostics, pathogen discovery and vaccines for rikettsial diseases. | |
| Session Chair: Diana Scorpio | |
| 3:05 PM | 1A. Plenary Overview: Advances in laboratory diagnosis of rickettsial diseases at the acute stage of illness - Cecilia Kato (188) |
| 3:30 PM | 1B. Detection and isolation of Rickettsia tillamookensis (Rickettsiales: Rickettsiaceae) from Ixodes pacificus (Acari: Ixodidae) from multiple regions of California - Chris Paddock (205) |
| 3:45 PM | 1C. Targeted mutagenesis in Anaplasma phagocytophilium for modified live vaccine development - Jonathan Ferm (118) |
| 4:00 PM | 1D. Combined diagnosis of ifa and pcr increase the confirmation of suspected spotted fever cases -Liliane Duraes (173) |
| 4:15 PM | 1E. An antigen-based diagnostic lateral-flow-assay for acute spotted fever rickettsioses - Rong Fang (178) |
| 4:30 PM | 1F. Targeted Mutagenesis in Anaplasma Marginale to Define Virulence and Vaccine Development Against Bovine Anaplasmosis - Roman Ganta (184) |
| 4:45 PM | Break |
| 5:00 PM | 1G. Mentoring Session: Transitioning to Early Career Stage Investigator - Lisa Brown, Lilian Crosby, Adela Olivia Chavez, Sean Riley, Rebecca Lamason, Dana Shaw |
| 6:00 PM | Welcome Reception |
| 6:30 PM | ASR Historical Lecture - Roman Ganta |
| Sunday June 26 | |
| Session 2: Tick-borne spotted fever group Rickettsia | |
| Session Chair: Sean Riley | |
| 8:35 AM | 2A. Keynote: Rickettsial disease: the delicate balance of microbial fitness and human genetic diversity - Steve Dumler |
| 9:20 AM | 2B. Invited Short Talk: Probing rickettsia pathogenesis using advanced biochemical and genetic tools - Rebecca Lamason (227) |
| 9:40 AM |
2C. Invited Short Talk: Selective fragmentation of the trans-Golgi apparatus by Rickettsia rickettsii - Ted Hackstadt (234) |
| 10:00 AM | 2D. Whole-genome sequencing of R. amblyommatis isolated from A. americanum in Long Island reveals unique genetic traits and phenotypes associated with mild rickettsioses - Hwan Kim (190) |
| 10:15 AM | 2E. Identification of transposon insertion mutants in pathogenic sfg Rickettsia species that are impaired in intracellular growth within mammalian phagocytic cells - Juan Martinez (196) |
| 10:30 AM | 2F. Classical complement activation, IgM, and anaphylatoxins shape the immune response to Rickettsia infection - Mustapha Dahmani (112) |
| 10:45 AM | Break |
| Session 3: Coxiella biology and pathogenesis. | |
| Session Chair: Dan Voth | |
| 11:00 AM |
3A. Plenary Overview: Lessons from an obligate stealth pathogen: Multiple ways to “skin a cat” - Jim Samuel (109) |
| 11:30 AM | 3B. Investigating the prophylactic and therapeutic potential of doxycycline using an A/J mouse aerosol model of Q-fever - Chris Jenkins (187) |
| 11:45 AM | 3C. Coxiella burnetii manipulates the type I interferon pathway in a T4BSS dependent manner - Erin van Schaik (217) |
| 12:00 PM | 3D. Development of a CRISPR interference system for genetic manipulation of the bacterial human pathogen Coxiella burnetii - Shaun Wachter (159) |
| 12:15 PM | 3E. Drosophila sting mediates Coxiella burnetii infection by regulating oxidative stress - Marena Guzman (121) |
| 12:30 PM | 3F. Identification and functional analysis of Coxiella burnetii dugway strain-specific type IV secretion system effector proteins - Mahelat Tesfamariam (151) |
| 12:45 PM | Lunch (Included) |
| 1:30 PM | Poster Session I - Even #s |
| Session 4: Anaplasma and Ehrlichia - vector transmitted, vacuolar bacterial genetic manipulations. | |
| Session Chair: Kelly Brayton | |
| 2:30 PM | 4A: Plenary overview: Anaplasma phagocytophilum: Getting around in ticks and humans - Uli Munderloh (200) |
| 3:00 PM |
4B. Keynote: Moonlighting on Steroids: Ehrlichia TRP Effectors, SLiMs and PTMs - Jere McBride (225) |
| 3:30 PM | 4C. Comparative whole genome analysis of an Anaplasma phagocyophilum strain isolated from Norwegian sheep - Francy L. Crosby (172) |
| 3:45 PM | 4D. Characterization of the HGE14 family of nuclear-localized T4SS effectors of Anaplasma phagocytophilum - Deirdre Fahy (115) |
| 4:00 PM | 4E. Anaplasma phagocytophilum HGE14 effectors: A viral tail - Ian Cadby (169) |
| 4:15 PM | 4F. OMP-1 and VirB2 immunization of dogs minimizes tick-transmission of Ehrlichia - Yasuko Rikihisa (211) |
| 4:30 PM | 4G. Ehrlichia SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes - LaNisha Patterson (226) |
| 4:45 PM | 4H. Types I and II interferon signaling and pathogenesis in the murine model of A. phagocytophilum infection - Andres Londono (126) |
| 5:00 PM | Reception and Poster Viewing |
| 6:00 PM | Business Meeting |
| 7:00 PM | Dinner (included) |
| Monday June 27 | |
| Session 5: Bacterial effectors and response regulators. | |
| Session Chair: Rahul Raghavan | |
| 8:30 AM | 5A. A transposon screen to identify potential essential genes in Coxiella burnetii - Georgie Metters (197) |
| 8:45 AM | 5B. Investigating mechanisms by which spotted fever group (sfg) rickettsiae induce microvascular endothelial cell barrier permeability - Jennifer Farner (117) |
| 9:00 AM | 5C. The CD36 homolog croquemort binds infection-derived lipids and initiates antibacterial immunity in Ixodes scapularis - Anya O’Neal (133) |
| 9:15 AM | 5D. Hacking the tick: Identification and characterization of a tick-targeted effector from Anaplasma phagocytophilum - Jason Park (206) |
| 9:30 AM | 5E. Pathogenic Rickettsia species manipulate host immune defense pathways to facilitate intracytosolic replication within the host - Oliver Voss (218) |
| 9:45 AM | Poster Session II - Odd #s |
| Session 6: Orientia biology and pathogenesis | |
| Session Chair: Allen Richards | |
| 10:45 AM | 6A: Plenary Overview: The intracellular lifecycle of Orientia tsutsugamushi - Jeanne Salje (230) |
| 11:15 AM | 6B: Invited Short Talk: Orientia tsutsugamushi host-pathogen interactions and new tools for discovery - Paige Allen (224) |
| 11:45 AM | 6C. Altered lethality associated with cytokine (IFNγ, TNF, and IL2) depletion in a non-lethal murine model of Orientia tsutsugamushi infection (compared to lethal and sublethal models) - Alison Fedrow (181) |
| 12:00 PM | 6D. Recognition of Vita-PAMPs in Orientia tsutsugamushi by endosomal RNA receptors - Christian Keller (189) |
| 12:15 PM | 6E. Orientia tsutsugamushi effector Ank5 decreases surface MHC-I levels by targeting the transcriptional activator, NLRC5, for proteasomal degradation -Haley Adcox (102) |
| 12:30 PM | 6F. A murine model of waning scrub typhus cross-protection between heterologous strains of Orientia tsutsugamushi - David Walker (219) |
| 1:00 PM | NIH Roundtable Discussion for Trainees & Early Career Investigators - Liangbiao Zheng, Samuel Perdue (box lunch included) |
| Moderator Joao Pedra | |
| Afternoon/Evening Free | |
| Tuesday June 28 | |
| Session 7: Vector contribution to rickettsial pathogenesis. | |
| Session Chair: Alyssa Snellgrove | |
| 8:30 AM | 7A: Plenary Overview: Arthropod vectors: More than mobile syringes - Dana Shaw |
| 9:00 AM | 7B. Targeting tick transporter to prevent rickettsial pathogen transmission - Girish Neelakanta |
| 9:30 AM | 7C. Anaplasma marginale infection of Dermacentor andersoni primary midgut cell culture is dependent on fucosylated glycans - Rubikah Vimonish (158) |
| 9:45 AM | 7D. A pleiotropic metabolite affects microbial infection and arthropod vector fitness - Sourabh Samaddar (142) |
| 10:00 AM | 7E. The use of the antigenically variable major surface protein 2 (msp2) in the establishment of superinfection during natural tick transmission of Anaplasma marginale in southern Ghana - Roberta Koku (123) |
| 10:15 AM | Break |
| Session 8: Genomic determinants of rickettsial lifestyles. | |
| Session Chair: Lisa Brown | |
| 10:45 AM | 8A: Plenary Overview: Drosophila melanogaster as a chassis for understanding bacterial effector targets of arthropods - Irene Newton (140) |
| 11:45 AM |
8B. Coxiella burnetii polysaccharide vaccine protects guinea pigs from coxiellosis - John Stenos (228) |
| 12:15 PM | 8C. Sticking together – Ixodes pacificus and symbiotic Rickettsia monacensis strain humboldt - Jianmin Zhong (222) |
| 12:30 PM | 8D. Determining transmission determinants of an emerging flea-borne rickettsiosis - Hanna Laukaitis (124) |
| 12:45 PM | Closing Remarks by the 2023 President |
